The Single-Use Revolution - Achieving High-Yield Cell Processing from Lab to Clinic
In the fast-paced world of biopharmaceuticals and cell & gene therapy, the integrity and viability of your cells are your most valuable assets. The process of isolating and concentrating cells, whether for a cell-based therapy or large molecule clarification, is often a critical bottleneck. To advance the human condition, you need a separation technology that maximises recovery without sacrificing quality.
As a specialist provider of scientific equipment and engineering support, we bring you the UniFuge platform of single-use centrifuges from CARR Biosystems.
Why Single-Use Centrifuges Are Essential for Today's Bioprocessing
The core challenge in cell processing is achieving maximum cell recovery (yield) while maintaining cell health (viability). Traditional methods often involve trade-offs. The UniFuge technology is designed to eliminate this compromise.
The UniFuge single-use systems are built with proven low-shear, tubular bowl technology. This design enables fast processing speeds while minimising the destructive shear forces common in other systems.
- Performance: We boast up to 98% product recovery and typical cell viability of 98% or higher. This high-yielding clarification is essential for shear-sensitive products.
- Scalability: The platform allows for seamless scale-up from early-stage development to cGMP manufacturing. You can start with the UFMicro® and UFMini® models, and scale all the way up to the U2K® for processing volumes of 2000+ litres.
- Ease of Use & Compliance: The fully automated system has a low footprint, offers manual operation options, and allows for set-up and changeover in under 15 minutes. Crucially, it provides a cGMP-compliant 21 CFR Part 11 data trail, simplifying your regulatory path.
This versatility means you can use UniFuge at any point in your cell processing workflow - for cell enrichment, washing/media change (low-shear media exchanges), or concentrating cell suspensions for final formulation.
The UniFuge Platform: Designed for Reliability and Versatility
The UniFuge single-use centrifuges offer variable G-forces up to 4,000×g. Each pre-sterilised single-use module is ready-to-use, minimising contamination risk and significantly reducing operational costs related to maintenance and cleaning validation.
Our UniFuge Family:
| Model | Min. Working Volume | Max. Flow Rate* | Key Feature |
| UFMini | 90mL or 300mL | 1000 mL/min | Ideal for early development and small batches. |
| UniFuge Pilot | 1L or 1.8L | 4 L/min | Bridging the gap from lab to early clinical scale. |
| U2K | 9 L | 20 L/min | Supporting large-scale cGMP manufacturing (up to 2000+ L batches). |
Whether you are isolating cell-based therapies, clarifying large molecules, or harvesting cultured meat products, UniFuge is engineered to deliver reliable results.
Looking for More Information?
If you require solutions for submicron particle separation or are exploring multi-use options, our selection of stainless steel centrifuges (PowerFuge and ViaFuge families) are also available.
Explore our featured resources below, including the whitepaper "Single-Use Centrifuges Are Transforming Biopharmaceutical Development and Manufacturing," to deepen your understanding.
Featured Resources:
- Article: Navigating the Challenges of iPSC Differentiation: The Advantages of Tubular Bowl Centrifuges in Media Exchange
- Case Study: Clarification of HEK293 Cells Using Centrifugation: Results from the UniFuge® Pilot and the UFMini
- Whitepaper: Single-Use Centrifuges Are Transforming Biopharmaceutical Development and Manufacturing
