Standard Configuration

Each Genesis system is supplied with a comprehensive standard specification designed to provide SIP bioprocessing capability. The standard configuration includes:

• Stainless-steel jacketed vessel with AISI 316L product contact surfaces and AISI 304 non-contact parts with a mirror-polished internal finish. Additional design features include:
  - Flat stainless-steel lid with retractable bolts
  - Toro-spherical bottom for effective drainage
  - Sterilisation and PID controlled thermoregulation using steam, - electrical heaters, or hybrid (steam & electrical) heating configuration
• High-precision agitation system with a brushless motor (0-1500 rpm), equipped with process specific impellers (Rushton, marine, or pitched-blade type)
• Thermal Mass Flow Controller (TMFC) for accurate air delivery, supplied with a 0.22 μm filter and process specific sparger (Toro or Sintered Type)
• Sensors (with cable and software):
  - PT100 temperature sensor
  - pH measurement via Hamilton EasyFerm digital sensor
  - Dissolved Oxygen (dO2) measurement via Hamilton VisiFerm digital optical sensor
• Process Control System (PCS), with 24” touchscreen HMI running the latest Leonardo supervisory control software, with 4 × integrated peristaltic pumps (Watson-Marlow 114FD/DV).
• Additional accessories included:
  - 3x removable baffles for microbial configuration
  - Sampling and harvest valves (non-SIP)
  - Gas outlet with 0.22 μm exhaust filter
  - 4-way sterile liquid addition system
  - Illuminated sight glass on the vessel lid, and circular sight glass on vessel side.
  - Automatic pressure and gas control
  - Starter kit including polysulfone connectors, 0.22 μm gas filters, silicone tubing, and spare plugs
  - Packaging in wooden crate for transport

Leonardo software is included for supervisory control and data acquisition, providing process visualisation, real-time trends, calibration tools, workflow management, alarms, data export, remote access, and optional Logic Parser functionality.

Optional Extras

The Genesis platform can be expanded with a wide range of optional configurations, allowing the system to be tailored to the process, facility, and level of automation required.

• Parallel operation of multiple units (up to 24 bioreactors) from a single HMI for higher-throughput and process development work.
• Sophisticated gas mixing strategies with up to 5 TMFCs, including N₂ for anaerobic processes, O₂ for oxygen enrichment, CO₂ for cell culture workflows, or a dedicated overlay line.
• A wide range of additional measurement and control options can be integrated directly into the PCS, including redox, conductivity, total and viable cell density, dCO₂, weight (vessel or feed bottles), and antifoam/level sensing.
• Upgrade from fixed-speed to variable-speed pumps (0–100 rpm) for enhanced control of feeding strategies.
• Integrate external modular pumps (e.g. stepper-driven or brushless peristaltic pumps).
• SIP sampling and harvesting options available (steam-heated / hybrid systems only).
• Gas out condenser to minimise evaporation losses.
• Analogue input/output options (0–10 V, 0-20 mA, 4–20 mA) for integration with third-party devices.
• Exhaust gas analysis (O₂ and CO₂) for automatic calculation of OUR, CER, and RQ. Data can be fed directly into Leonardo.

Additional accessories are available including wheeled cart, chiller unit, steam generator, inoculation port, autoclavable feed bottles, and spare parts kits.

Leonardo is the Process Control System (PCS) software installed across the full Solaris product range, including benchtop bioreactors and fermenters, pilot and industrial systems, and tangential flow filtration (TFF) platforms. Using a common software environment across all scales helps simplify training, day-to-day operation, and process scale-up.

The software is web-based and supplied on a 24” all-in-one touchscreen interface running a Linux operating system. Leonardo communicates with one or more Siemens PLCs to control, monitor, and record all relevant process parameters throughout cultivation or filtration runs.

Real-time process data is displayed clearly to the user, providing immediate visibility of key operating conditions and system performance. Historical data logging, trend analysis, and process records are also available to support development work, optimisation, and batch traceability.

Leonardo is designed to be intuitive and easy to navigate. Pages are clearly structured around their relevant functions, allowing users to access controls, trends, recipes, calibration tools, and alarms efficiently. An integrated context-help manual is included within the software, explaining the purpose of each on-screen function and helping new users become confident quickly.

The result is a powerful yet user-friendly control platform that supports both routine operation and advanced process development, while maintaining a consistent user experience from benchtop scale through to production systems.

LEM_1 is Solaris’ advanced Process Control System (PCS) for benchtop bioreactors and fermenters from 200 mL to 20 L, developed to deliver reliable automation, efficient operation, and straightforward scalability. It is integrated across Solaris benchtop platforms including IO, Jupiter, and Genesis, providing a consistent control environment across multiple systems.

Its compact, stackable cabinet design helps maximise valuable laboratory space while housing all core automation functions within a single, organised platform.

Key features include:

• Siemens S7 PLC-based control for stable communication, dependable performance, and simple integration of external accessories or future expansions.
• Leonardo 3.2 software operated through a 24” touchscreen interface, capable of managing up to 24 parallel processes from one control station.
• Modbus communication protocol for fast, accurate data acquisition with reduced signal noise and dependable sensor integration.
• Integrated Watson-Marlow pumps with software-assignable functions for feeds, acid/base dosing, antifoam, and other process requirements.
• Service-friendly design, including rear-facing utility connections and a sliding access panel for easier installation, maintenance, and routine servicing.

LEM_1 provides a robust and user-friendly automation platform that simplifies day-to-day operation while giving users the control and flexibility required for modern bioprocess development.

Solaris Biotech ​benchtop fermenters and bioreactors​ ​offer efficient platforms for R&D and product development applications. Their broad range of products are flexible and easy to use, ensuring there is always a solution specific to your needs and requirements – from research scale of a few hundred ml up to cGMP production of > 2000L.

Benefits include compact and user friendly designs, parallel software platform, up-to-date and open communication protocols.

The product range is used in universities, schools and research centres, as well as in pharma, nutraceutical, cosmeceutical, chemical, agricultural, and food and beverage industries, not to mention bioplastics and biofuels applications.

Solaris Tangential Flow Filtration (TFF) systems, fully automated within the ​Kronos​ product line, combine industrial elements and a compact design. For larger scale TFF applications open to customisation, consider the Tytan platform.