Biotechnology: Proving solutions to help you optimise your process

Laboratory Scale-Up & Cultivation

The journey begins with robust cultivation, where environmental control is the primary driver of biomass yield.

• Innovative Shake Flasks: Optimise initial cell expansion with Thomson Ultra Yield Flasks, which offer significantly higher working volumes and superior oxygen transfer rates over standard Erlenmeyer flasks for more efficient scale-up.
• High-Precision Fermentation: Achieve maximum microbial productivity through Solaris Biotech’s range of fermenters and bioreactors, providing advanced control across a versatile capacity range from 200mL up to 10,000L.
• Real-Time Monitoring: Maintain a continuous window into your culture with ABER’s Optura non-invasive biomass sensors, providing real-time insights into cell concentration to help you pinpoint optimal harvest times without the risk of manual sampling.

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Harvesting & Intracellular Product Recovery

Moving from cultivation to harvest and recovery requires technologies capable of managing complex separations and high pressure cell disruption without compromising the integrity of sensitive target molecules.

• High-G Continuous Centrifugation: The Carr Biosystems PowerFuge range utilises high g-force separation (20,000g) to provide high-efficiency recovery of bacteria, yeast, and proteins from even the most challenging liquid-solid solutions.
• Efficient Cell Disruption: Constant Systems high-pressure disruptors achieve 99% lysis efficiency in a single pass, offering a controlled alternative to traditional homogenisers that protects enzymes and nucleic acids from thermal degradation.

Precise Fluid Management

Maintaining the tertiary structure of proteins during chromatography and filtration requires gentle, consistent conveyance coupled with high-precision flow control.

• Low-Shear Transfer: Quattroflow quaternary diaphragm pumps utilise a unique four-piston design to provide the constant, low-pulsation flow essential for protecting sensitive biological molecules from damage.
• Precision Control and Scalability: Integrated with CPC Biotech flow measurement solutions, these systems ensure high-accuracy control and reliable performance as processes scale from benchtop research to full industrial production.